学位 博士

政治面貌 民盟盟员

邮箱 chennan@mail.hzau.edu.cn

研究方向 鱼类病毒与宿主相互作用机制；细胞自噬机制；生物富集和毒性作用机制研究

教育经历

2002/09 - 2007/07，武汉大学，生命科学学院生物化学系，博士，导师：梁毅；
1998/09 - 2002/07，华中师范大学，生命科学学院生物化学系，学士。

主要职历

2008/04至今，必威BETWAY官网，必威BETWAY官网水产动物医学系，讲师。
2013/09 - 2014/09 加拿大达尔豪斯大学，土木工程系水资源研究中心，访问学者。合作导师：Graham Gagnon 教授。

科研成果

1. 培育专项（国家基金预研项目），2662016PY028，II型GCRV结构蛋白VP56在病毒感染过程中的功能研究、2016/01-2016/12、10万元、已结题、主持

2. 水沙科学与水利水电工程国家重点实验室开放基金、sklhse-2012-B-06、丹江口库区食物网汞富集特征研究、2012/01-2014/12、7万元、已结题、主持

3. 湖北省自然科学基金一般项目、2009CDB424、草鱼肠道芽孢杆菌产纤维素酶的酶学性质研究 2009/01-2012/12、2万元、已结题、主持

4. 必威BETWAY官网校自主科技创新基金，2011QC074、草鱼肠道细菌纤维素酶的热变性研究、2011/01-2012/12、6万元、已结题、主持

5. 国家自然科学基金面上项目、31372563、鱼类神经坏死病毒B2蛋白线粒体定位对病毒的复制调控、80万元、2014/01-2017/12、80万元、在研、参加。

6. 国家自然科学基金青年基金，31000249、微囊藻毒素对大鼠认知的影响、2010/1-2012/12、20万元、已结题、参加

7. 湖北省自然科学基金青年杰出人才计划，2010CDA095、微囊藻毒素对鱼类生殖系统影响的研究、2010/01-2012/12、30万元、已结题、参加

8. 国家水体污染控制与治理科技重大专项，2009ZX07527-005、底栖动物（摇蚊幼虫）活体毒性测试关键技术、2009/01-2011/12、40万元、已结题、参加

成果列表：

到目前为止共发表15篇SCI收录文章（JCR一区文章5篇），其中第一/通讯作者文章5篇（JCR一区文章4篇，影响因子均高于3.0）。  

2017年：

Jiali Jin#, Yao Wang#, Zhixin Wu, Abeer Hergazy, Jiangfeng Lan, Lijuan Zhao, Xiaoling Liu, Nan Chen*, Li Lin*, Transcriptomic analysis of liver from grass carp (Ctenopharyngodon idellus) exposed to high environmental ammonia reveals the activation of antioxidant and apoptosis pathways. Fish & Shellfish Immunology, 2017, 63: 444-451  

2016年：

1. YaoWang#, Nan Chen#, Abeer M. Hegazy, Xiaodan Liu, Zhixin Wu, Xueqin Liu , Lijuan Zhao, Qiwei Qin, Jiangfeng Lan*, Li Lin*, Autophagy induced by snakehead fish vesiculovirus inhibited its replication in SSN-1 cell line, Fish & Shellfish Immunology, 2016, 55: 415-422.

2. JiangFeng Lan, ShunWei, Yu-QingWang, Yun-Jia Dai, Jia-Gang Tu, Li-Juan Zhao, XinCang Li, QiWei Qin, Nan Chen*, Li Lin*, PcToll3 was involved in anti-Vibrio response by regulating the expression of antimicrobial peptides in red swamp crayfish, Procambarus clarkii, Fish & Shellfish Immunology, 2016, 57:17-24.

3. Xiaodan Liu#, Jiagang Tu#*, Junfa Yuan, Xueqin Liu, Lijuan Zhao, Farman Ullah Dawar, Muhammad Nasir Khan Khattak, Abeer M. Hegazy, Nan Chen, Vikram N. Vakharia and Li Lin*, Identification and Characterization of MicroRNAs in Snakehead Fish Cell Line upon Snakehead Fish Vesiculovirus Infection, International Journal of Molecular Sciences, 2016, 17(2):154.

4. Ruixue Hu, Na Du, Nan Chen, Li Lin, Yanhua Zhai, Zemao Gu*, Molecular analysis of type II topoisomerases of Aeromonas hydrophila isolated from fish and levofloxacin-induced resistant isolates in vitro, Folia Microbiologica (Praha), 2016, 61(3): 249-253.

2015年：

1. Liqiang Xie, Wei Yan, Jing Li, Liqin Yu, Jianghua Wang, Guangyu Li*, Nan Chen*, Alan D. Steinman, Microcystin-RR exposure results in growth impairment by disrupting thyroid endocrine in zebrafish larvae, Aquatic Toxicology, 2015, 164: 16-22.

2. Feifei Zheng, Muhammad Asim, Jiangfeng Lan, Lijuan Zhao, Shun Wei, Nan Chen, Xiaoling Liu, Yang Zhou*, and Li Lin*, Molecular Cloning and Functional Characterization of Mannose Receptor in Zebra Fish (Danio rerio) during Infection with Aeromonas sobria, International Journal of Molecular Sciences, 2015, 16(5): 10997-11012.  

2014年：

1. Cheng Zeng, Hong Sun, Ping Xie, Jianghua Wang, Guirong Zhang, Nan Chen, Wei Yan*, Guangyu Li*, The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos, Aquatic Toxicology, 2014, 149: 25-32.

2. Guangyu Li,Wei Yan, Fei Cai, Cairong Li, Nan Chen, JianghuaWang*, Spatial learning and memory impairment and pathological change in rats induced by acute exposure to microcystin-LR, Environmental Toxicology, 2014, 29(3): 261-268.        

3. Li Wang, Lichun Liu, Yang Zhou, Xiaoheng Zhao, Mingjun Xi, Shun Wei, Rui Fang, Wei Ji, Nan Chen, Zemao Gu, Xueqin Liu, Weimin Wang, Muhammad Asim, Xiaoling Liu*, Li Lin*, Molecular cloning and expression analysis of mannose receptor C type 1 in grass carp (Ctenopharyngodon idella), Developmental and Comparative Immunology, 2014, 43(1): 54-58.

4. Jie Mei, Wei Yan, Jie Fang, Gailing Yuan, Nan Chen,Yan He*, Identification of a gonad-expression differential gene insulin-like growth factor-1 receptor (Igf1r) in the swamp eel (Monopterus albus), Fish Physiology and Biochemistry, 2014, 40(4): 1181-1190.

5. Xiaolin Liu, Xiaocheng Tang, Li Wang, Jie Li, Hong Wang, Shun Wei, Rui Fang, Wei Ji, Gailing Yuan, Nan Chen, Zemao Gu, Xueqin Liu, Weimin Wang, Muhammad Asim, Yang Zhou* and Li Lin*, Molecular cloning and expression analysis of mannose receptor in blunt snout bream (Megalobrama amblycephala), Molecular Biology Reports, 2014, 41(7): 4601-4611.  

2013年以前：

1. Nan Chen, Jun-Bao Fan, Jin Xiang, Jie Chen, Yi Liang*, Enzymatic hydrolysis of microcrystalline cellulose in reverse micelles，Biochimica et Biophysica Acta, 2006, 1764:1029-1035.

2. Jin Xiang, Jun-Bao Fan, Nan Chen, Yi Liang*, Interaction of cellulase with sodiumdodecyl sulfate at critical micelle concentration level, Colloid Surface. B-Biointerfaces, 2006, 49(2):175-180.

3. Xiang, Jin, Liang, Yi*, Chen, Nan Studies on the binding of sodium dodecyl sulfate to cellulase by isothermal titration calorimetry and fluorescence titration，Acta Chimica Sinica，2003，61(12):1949-1954  

授权发明专利：

梁毅, 陈楠, 范俊宝, 项瑾, 周拯, 陈杰, 一种用于降解纤维素的反胶束方法，2006.8.30，中国，ZL200510018944.2

备注

2011/05-2012/12 主持必威BETWAY官网自主科技创新基金，2011QC030，Nramp 基因多态性与黄颡鱼对