职称：教授

学位：博士

政治面貌：中共党员

邮箱：tujiagang@mail.hzau.edu.cn

研究方向：鱼类病毒致病机理及免疫防控

教育经历

2002.09-2006.06 必威BETWAY官网生命科学技术学院，获学士学位

2006.09-2011.12 必威BETWAY官网动物科学技术学院动物医学院，获博士学位

主要职历

2012.09-2015.05 美国德州大学休斯敦健康科学中心, 博士后

2015.10-2017.09 必威BETWAY官网 必威BETWAY官网，师资博士后

2017.10-2023.10 必威BETWAY官网 必威BETWAY官网，副教授

2023.11-至今 必威BETWAY官网 必威BETWAY官网，教授

科研成果

主持科研项目

1. 国家重点研发计划子课题，大宗淡水鱼类出血病的发生机制及传播阻断技术研究，2023.12-2027.12，42万，在研

2. 国家自然科学基金面上项目，聚合酶复合物L-P通过泛素化修饰调节乌鳢水泡病毒增殖和毒力的分子机制研究，2022.01-2025.12，58万，在研

3. 国家自然科学基金面上项目，Leader RNA与N蛋白互作调节乌鳢水泡病毒增殖的分子机制研究，2020.01-2023.12，58万，已结题

4. 横向项目，鱼类病毒病疫苗和药物研发，2020.01-2022.12，60万，已结题

5. 国家自然科学基金青年项目，MiR-214在乌鳢水泡病毒感染SSN-1细胞中的调控机制研究，2017.01-2019.12，20万，已结题

6. 中央高校科研业务费，乌鳢水泡病毒P蛋白异构体P3的功能研究， 2018.01-2020.12，20万，已结题

7. 横向项目，乌鳢水泡病毒减毒疫苗的研制，2019.01-2019.12，10万，已结题

8. 中国博士后科学基金，乌鳢水泡病毒调控宿主microRNA的机制研究， 2017.01-2018.12，8万，已结题

代表性科研论文

1. Xiangmou Qin, Ningyan Jiang, Jingjing Zhu, Yong-An Zhang*, Jiagang Tu*. Snakehead vesiculovirus hijacks SH3RF1 for replication via mediating K63-linked ubiquitination at K264 of the phosphoprotein. International Journal of Biological Macromolecules, 2024, 255:128201.

2. Chu Zhang, Hui Wu, Hao Feng, Yong-An Zhang*, Jiagang Tu*. Grass carp reovirus VP56 and VP35 induce formation of viral inclusion bodies for replication. iScience, 2023, 27(1):108684.

3. Xiangmou Qin, Yong-An Zhang*, Jiagang Tu*. P38MAPK- and GSK3-mediated phosphorylation of snakehead vesiculovirus phosphoprotein at threonine 160 facilitates viral replication. Journal of Virology, 2023, 97(5): e0040423.

4. An-Qi Liu, Xiangmou Qin, Hui Wu, Hao Feng, Yong-An Zhang*, Jiagang Tu*. hnRNPA1 impedes snakehead vesiculovirus replication via competitively disrupting viral phosphoprotein-nucleoprotein interaction and degrading viral phosphoprotein. Virulence, 2023, 14(1): 2196847.

5. Congran Bei^#, Chu Zhang^#, Hui Wu, Hao Feng, Yong-An Zhang, Jiagang Tu*. DDX3X is hijacked by snakehead vesiculovirus phosphoprotein to facilitate virus replication via stabilization of the phosphoprotein. Journal of Virology, 2023, 97(2): e0003523.

6. Chi Zhang, An-Qi Liu, Chu Zhang, Lan-Hao Liu, Jianguo Su, Yong-An Zhang*, Jiagang Tu*. MicroRNA miR-722 inhibits cyprinid herpesvirus 3 replication via targeting the viral immune evasion protein ORF89, which negatively regulates IFN by degrading IRF3. Journal of Immunology, 2022, 209(10):1918-1929.

7. Lin Jiang, An-Qi Liu, Chu Zhang, Yong-An Zhang*, Jiagang Tu*. Hsp90 regulates GCRV-II proliferation by interacting with VP35 as its receptor and chaperone. Journal of Virology, 2022, 96(19): e0117522.

8. Yanwei Zhang, Yong-An Zhang*, Jiagang Tu*. Hsp90 is required for snakehead vesiculovirus replication via stabilization of the viral L protein. Journal of Virology, 2021, 95(16): e0059421.

9. Xiangmou Qin^#, Shuangshuang Feng^#, Yanwei Zhang, Jianguo Su, Li Lin, Yong-An Zhang*, Jiagang Tu*. Leader RNA regulates snakehead vesiculovirus replication via interacting with viral nucleoprotein. RNA Biology, 2021, 18(4): 537-546.

10. Shuangshuang Feng, Jianguo Su, Li Lin*, Jiagang Tu*. Development of a reverse genetics system for snakehead vesiculovirus (SHVV), Virology, 2019, 526: 32-37.

11. Chunyan Wang#, Jiagang Tu#, Jun Liu*, Ian J. Molineux*. Structural dynamics of bacteriophage P22 infection initiation revealed by Cryo-electron tomography. Nature Microbiology, 2019, 4(6): 1049-56.

12. Chi Zhang, Shuangshuang Feng, Wenting Zhang, Nan Chen, Abeer M. Hegazy, Wenjie Chen, Xueqin Liu, Lijuan Zhao, Jun Li, Li Lin*, Jiagang Tu*. MicroRNA miR-214 inhibits snakehead vesiculovirus replication by promoting IFN-a expression via targeting host adenosine 5’-monophosphate-activated protein. Frontiers in immunology, 2017, 8:1775.

13. Chi Zhang, Lizhu Yi, Shuangshuang Feng. Xueqin Liu, Jianguo Su, Li Lin, Jiagang Tu*. MicroRNA miR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting the coding regions of viral N and P. Journal of General Virology, 2017, 98(7): 1611-1619.

14. 伊丽竹，徐镇，林蠡，涂加钢*. miRNA在乌鳢水泡病毒感染月鳢细胞（SSN-1）中的表达变化及其调控作用. 水产学报. 2019, 43(5): 1288-1297.

15. 秘琮然，张永安，涂加钢*. 乌鳢水泡病毒P蛋白异构体的鉴定及其功能初探. 水产学报. 2021, 45(9): 1508-1516.

授权发明专利

1. 涂加钢，张永安。一种构建赤点石斑鱼神经坏死病毒反向遗传系统的方法。专利号: ZL202010239788.7; 授权公告日: 2022.03.08

2. 金梅林，涂加钢，周红波，徐晓娟，陈焕春。一种重组H5N1禽流感细胞苗及应用。专利号: ZL201010620151.9; 授权公告日: 2013.12.30

备注

入选国家级青年人才项目

研究方向：主要围绕草鱼出血病、乌鳢水泡病毒病、加州鲈虹彩病毒病开展致病机理及免疫防控（口服/浸泡疫苗）研究